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SANT-2

Names

[ CAS No. ]:
329196-48-7

[ Name ]:
SANT-2

[Synonym ]:
sant-2

Biological Activity

[Description]:

SANT 2 is a potent antagonist of Hh-signaling pathway. Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. SANT 2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Stem Cell/Wnt >> Hedgehog

[References]

[1]. Büttner A, et al. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorg Med Chem. 2009 Jul 15;17(14):4943-54.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H26ClN3O4

[ Molecular Weight ]:
479.95500

[ Exact Mass ]:
479.16100

[ PSA ]:
85.47000

[ LogP ]:
6.40470

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Statements ]:
H413

[ RIDADR ]:
NONH for all modes of transport

Related Compounds