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Sanggenol L

Names

[ CAS No. ]:
329319-20-2

[ Name ]:
Sanggenol L

[Synonym ]:
4H,8H-Benzo[1,2-b:3,4-b']dipyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3,9,10-tetrahydro-5-hydroxy-8-methyl-8-(4-methyl-3-penten-1-yl)-
2-(2,4-Dihydroxyphenyl)-5-hydroxy-8-methyl-8-(4-methyl-3-penten-1-yl)-2,3,9,10-tetrahydro-4H,8H-pyrano[2,3-f]chromen-4-one

Biological Activity

[Description]:

Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells[1]. Sanggenol L induces of apoptosis via suppression of PI3K/Akt/mTOR signaling and cell cycle arrest via activation of p53 in p

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> MDM-2/p53

[References]

[1]. Won YS, Seo KI. Sanggenol L promotes apoptotic cell death in melanoma skin cancer cells through activation of caspase cascades and apoptosis-inducing factor. Food Chem Toxicol. 2020;138:111221.

[2]. Won YS, Seo KI. Sanggenol L Induces Apoptosis and Cell Cycle Arrest via Activation of p53 and Suppression of PI3K/Akt/mTOR Signaling in Human Prostate Cancer Cells. Nutrients. 2020;12(2):488. Published 2020 Feb 14.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
660.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H26O6

[ Molecular Weight ]:
422.47

[ Flash Point ]:
226.4±25.0 °C

[ Exact Mass ]:
424.188599

[ LogP ]:
6.65

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.608

Related Compounds