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FM19G11

Names

[ CAS No. ]:
329932-55-0

[ Name ]:
FM19G11

[Synonym ]:
fm19g11

Biological Activity

[Description]:

FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC50 of 80 nM in HeLa cells. FM19G11 modulates other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactivated under normoxic conditions[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Research Areas >> Neurological Disease

[Target]

HIF-1α[1]


[In Vitro]

FM19G11 (30-300 nM) inhibits HIFα proteins in the HeLa cell lines[1]. FM19G11 (500 n m) promotes oligodendrocyte differentiation under hypoxia[1]. FM19G11 (300 nM; 3 days) suppresses the mRNA levels of O6-methylguanine DNA-methyltransferase (MGMT) significantly in hypoxic GBM‐XD, hypoxic T98G, and normoxic T98G cells[2]. M19G11 (300 nM; 3 days) significantly enhances the pro‐apoptotic effect of temozolomide (TMZ), although FM19G11 does not induce apoptosis by itself[2]. Cell Viability Assay[2] Cell Line: GBM‐XD and T98G cells Concentration: 300 nM Incubation Time: 3 days Result: Suppressed MGMT expression significantly in both cell lines in hypoxic culture. Downregulated MGMT expression substantially inT98G cells in normoxic culture. Cell Viability Assay[2] Cell Line: GBM‐XD and T98G cells Concentration: 300 nM Incubation Time: 3 days Result: Had no cytotoxicity by itself. Enhanced the cytotoxicity of TMZ in hypoxic GBM-XD cells, hypoxic T98G cells, and normoxic T98G cells.

[In Vivo]

FM19G11 ( intramedullary injection; 1-8 weeks) improve locomotion in severe spinal cord injury (SCI) [3]. FM19G11 ( intramedullary injection; 8 weeks) induces the expression of GAP43, an axon growth marker, and RIP, a marker for myelinated oligodendrocytes at the injury[3].

[References]

[1]. Victoria MM, et, al. FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. J Biol Chem. 2010 Jan 8; 285(2): 1333-42.

[2]. You CG, et, al. FM19G11 inhibits O 6 -methylguanine DNA-methyltransferase expression under both hypoxic and normoxic conditions. Cancer Med. 2018 May 15; 7(7): 3292-3300.

[3]. Ana AA, et, al. FM19G11 and Ependymal Progenitor/Stem Cell Combinatory Treatment Enhances Neuronal Preservation and Oligodendrogenesis after Severe Spinal Cord Injury. Int J Mol Sci. 2018 Jan 9; 19(1): 200.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H17N3O8

[ Molecular Weight ]:
463.39600

[ Exact Mass ]:
463.10200

[ PSA ]:
167.60000

[ LogP ]:
5.53380

[ Appearance of Characters ]:
powder，off-white to light brown

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

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