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ent-16β,17-Dihydroxykauran-19-oic acid

Names

[ CAS No. ]:
3301-61-9

[ Name ]:
ent-16β,17-Dihydroxykauran-19-oic acid

[Synonym ]:
16,17-dihydroxykaurenic acid
(5β,8α,9β,10α,13α,16β)-16,17-Dihydroxykauran-18-oic acid

Biological Activity

[Description]:

ent-16β,17-Dihydroxykauran-19-oic acid is an anti-inflammatory agent, which can be isolated from Siegesbeckia pubescens herb. ent-16β,17-Dihydroxykauran-19-oic acid inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Lee M, et al. ent-kaurane and ent-pimarane diterpenes from Siegesbeckia pubescens inhibit lipopolysaccharide-induced nitric oxide production in BV2 microglia. Biol Pharm Bull. 2014;37(1):152-7.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
505.6±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H32O4

[ Molecular Weight ]:
336.47

[ Flash Point ]:
273.6±22.4 °C

[ Exact Mass ]:
336.230072

[ PSA ]:
77.76000

[ LogP ]:
3.28

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.577

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds