Monoethyl pimelate

Names

[ Name ]:
Monoethyl pimelate

[Synonym ]:
Monoethyl Heptanedioate
BOC-HIS(TOS)-MBHA RESIN
BOC-L-HIS(TOS)-MBHA RESIN
heptanedioic acid monoethyl ester
6-(ethoxycarbonyl)hexanoic acid
PAM BOC-L-HISTIDINE (TOS)
7-ethoxy 7-oxo heptanoic acid
Monoethyl PiMelate
BOC-HIS(TOS)-CMS RESIN
pimelicacidmonethylester
MFCD00801202
Pimelic Acid Monoethyl Ester
BOC-HIS(TOS)-BHA PS RESIN
Ethyl hydrogen pimelate
BOC-HIS(TOS)-BHA RESIN
EINECS 251-346-6
BOC-HIS(TOS)-PAM RESIN

Biological Activity

[Description]:

Monoethyl pimelate is a PROTAC linker, which refers to the alkyl/ether composition. Monoethyl pimelate can be used in the synthesis of (S,R,S)-AHPC-Me-C7 ester, a specific BCL-XL PROTAC degrader[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[References]

[1]. Khan S, et al. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nat Med. 2019 Dec;25(12):1938-1947.

Chemical & Physical Properties

[ Density]:
1.074 g/cm3

[ Boiling Point ]:
135-138ºC 1mm

[ Melting Point ]:
10ºC

[ Molecular Formula ]:
C₉H₁₆O₄

[ Molecular Weight ]:
188.22100

[ Flash Point ]:
108ºC

[ Exact Mass ]:
188.10500

[ PSA ]:
63.60000

[ LogP ]:
1.58460

[ Index of Refraction ]:
1.442

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Not miscible or difficult to mix with water.

MSDS

Click to get detail MSDS

Safety Information

[ Risk Phrases ]:
R36/38

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
3

[ HS Code ]:
2918990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%