4-nitrocatechol

Names

[ Name ]:
4-nitrocatechol

[Synonym ]:
EINECS 222-009-0
1,2-Benzenediol, 4-nitro-
1,2-dihydroxy-4-nitrobenzene
[14C]-4-Nitrocatechol
NITROCATECHOL (MIX OF ISOMERS)
4-nitrocathecol
3,4-dihydroxynitrobenzene
4-Nitro-1,2-benzenediol
4-nitrocatechol
4-Nitrobenzol-1,2-diol
MFCD00007242
4-Nitropyrocatechol
4-nitrobenzene-1,2-diol

Biological Activity

[Description]:

4-Nitrocatechol is a potent lipoxygenase inhibitor[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[Target]

Human Endogenous Metabolite

Microbial Metabolite

[References]

[1]. Ewa Skrzypczak-Jankun, et al. Soybean lipoxygenase-3 in complex with 4-nitrocatechol. Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):613-5.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
358.2±32.0 °C at 760 mmHg

[ Melting Point ]:
173-177 °C(lit.)

[ Molecular Formula ]:
C₆H₅NO₄

[ Molecular Weight ]:
155.108

[ Flash Point ]:
168.8±13.6 °C

[ Exact Mass ]:
155.021851

[ PSA ]:
86.28000

[ LogP ]:
1.68

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.668

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2908999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2908999090

[ Summary ]:
2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Effect of commercially available green and black tea beverages on drug-metabolizing enzymes and oxidative stress in Wistar rats.

Food Chem. Toxicol. 70 , 120-7, (2014)

The effect of commercially available green tea (GT) and black tea (BT) drinks on drug metabolizing enzymes (DME) and oxidative stress in rats was investigated. Male Wistar rats were fed a laboratory c...

Molecular characterization of the boron adducts of the proteasome inhibitor bortezomib with epigallocatechin-3-gallate and related polyphenols.

Org. Biomol. Chem. 13(13) , 3887-99, (2015)

The green tea polyphenol epigallocatechin-3-gallate (EGCG) was reported to effectively antagonize the ability of Bortezomib (BZM) to induce apoptosis in cancer cells. This interaction was attributed t...

Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.

Drug Metab. Dispos. 43(1) , 126-39, (2014)

Although skin is the largest organ of the human body, cutaneous drug metabolism is often overlooked, and existing experimental models are insufficiently validated. This proof-of-concept study investig...