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IMR-1A

Names

[ CAS No. ]:
331862-41-0

[ Name ]:
IMR-1A

[Synonym ]:
acetic acid, 2-[4-[(E)-(2-mercapto-4-oxo-5(4H)-thiazolylidene)methyl]-2-methoxyphenoxy]-
Acetic acid, 2-[2-methoxy-4-[(E)-(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-
{2-Methoxy-4-[(E)-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetic acid
[2-Methoxy-4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-acetic acid
MFCD08681051
IMR-1A

Biological Activity

[Description]:

IMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L.target: NotchIC 50: 6 μmol/LIn vitro: IMR-1 prevents the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth .A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared with the control (DMSO).In vivo : The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish.

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Notch
Research Areas >> Cancer

[References]

[1]. Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.


[Related Small Molecules]

RO4929097 | Crenigacestat(LY3039478) | YO-01027 | LY-411575 | Tangeretin | FLI-06 | Avagacestat | IMR-1 | BMS-983970 | Semagacestat(LY450139) | Z-Ile-Leu-aldehyde | Psoralidin | tCFA15

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C13H11NO5S2

[ Molecular Weight ]:
325.360

[ Exact Mass ]:
325.007874

[ LogP ]:
0.78

[ Appearance of Characters ]:
yellow solid

[ Index of Refraction ]:
1.699

[ Storage condition ]:
-20℃

Related Compounds