Bax channel blocker

Names

[ CAS No. ]:
335165-68-9

[ Name ]:
Bax channel blocker

[Synonym ]:
Bax channel blocker

Biological Activity

[Description]:

BAI1 is a direct allosteric inhibitor of BAX.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Research Areas >> Cancer

[Target]

BAX[1]

[References]

[1]. Garner TP, et al. Small-molecule allosteric inhibitors of BAX. Nat Chem Biol. 2019 Apr;15(4):322-330.

Chemical & Physical Properties

[ Boiling Point ]:
388.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₃Br₂Cl₂N₃O

[ Molecular Weight ]:
540.11900

[ Flash Point ]:
188.5ºC

[ Exact Mass ]:
536.95800

[ PSA ]:
40.43000

[ LogP ]:
5.45630

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%