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Voacamine

Names

[ CAS No. ]:
3371-85-5

[ Name ]:
Voacamine

[Synonym ]:
Dodecandisaeure-monomethylester
methyl hydrogen dodecanedioate
monomethyl-dodecanedioate
epi-Voacamin
methyl ester of 1,12-dodecanedioic acid,dimethyl ester
Dodecanedioic acid monomethyl ester
11MeOCO undec acid
Voacamine

Biological Activity

[Description]:

Voacamine, an indole alkaloid, isolated from Voacanga Africana, exhibits potent cannabinoid CB1 receptor antagonistic activity[1]. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein
Research Areas >> Metabolic Disease
Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[References]

[1]. Kitajima M, et al. Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1962-4.

[2]. Meschini S, et al. Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells. Int J Oncol. 2005 Dec;27(6):1597-603.

Chemical & Physical Properties

[ Density]:
1.309g/cm3

[ Melting Point ]:
223℃

[ Molecular Formula ]:
C43H52N4O5

[ Molecular Weight ]:
704.89700

[ Exact Mass ]:
704.39400

[ PSA ]:
99.89000

[ LogP ]:
6.36470

[ Index of Refraction ]:
1.674

[ Storage condition ]:
2-8℃

Related Compounds