ICA

Names

[ Name ]:
ICA

[Synonym ]:
N-[4-(2-Pyridinyl)-1,3-thiazol-2-yl]-2-pyridinamine
Pyridin-2-yl-(4-pyridin-2-yl-thiazol-2-yl)-amine
TCMDC-124275
N-[4-(Pyridin-2-yl)-1,3-thiazol-2-yl]pyridin-2-amine
2-Pyridinamine, N-[4-(2-pyridinyl)-2-thiazolyl]-

Biological Activity

[Description]:

ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Cardiovascular Disease

Research Areas >> Infection

[Target]

IC50: 2.1 µM (Antileishmanial)[1]

[In Vitro]

The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters[2].

[References]

[1]. Bhuniya D, et al. Aminothiazoles: Hit to lead development to identify antileishmanial agents. Eur J Med Chem. 2015 Sep 18;102:582-93.

[2]. Skibsbye L, et al. Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium. J Cardiovasc Pharmacol. 2015 Aug;66(2):165-76.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
466.4±48.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₀N₄S

[ Molecular Weight ]:
254.310

[ Flash Point ]:
235.9±29.6 °C

[ Exact Mass ]:
254.062622

[ LogP ]:
1.39

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.694

[ Storage condition ]:
2-8℃

ICA

Names

Biological Activity

Chemical & Physical Properties

Related Compounds