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Lorvotuzumab

Names

[ CAS No. ]:
339306-30-8

[ Name ]:
Lorvotuzumab

Biological Activity

[Description]:

Lorvotuzumab (Anti-NCAM1/CD56 Reference Antibody (lorvotuzumab)) is a humanized monoclonal antibody that binds CD56 (NCAM1). Lorvotuzumab can be used to synthesize an ADC compound, Lorvotuzumab mertansine[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Lorvotuzumab mertansine (IMGN901) 是一种 ADC，可通过二硫键连接强效抗有丝分裂 (DM1) 与 CD56 靶向抗体 (Lorvotuzumab)。 Lorvotuzumab mertansine 抗肾母细胞瘤、横纹肌肉瘤和神经母细胞瘤。

[References]

[1]. James I Geller, et al. ADVL1522: A phase 2 study of lorvotuzumab mertansine (IMGN901) in children with relapsed or refractory wilms tumor, rhabdomyosarcoma, neuroblastoma, pleuropulmonary blastoma, malignant peripheral nerve sheath tumor, or synovial sarcoma-A Children's Oncology Group study. Cancer. 2020 Dec 15;126(24):5303-5310.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds