Pterosin B

Names

[ Name ]:
Pterosin B

[Synonym ]:
1-Indanone, 6-(2-hydroxyethyl)-2,5,7-trimethyl-, (-)-
6-(2-hydroxyethyl)-2,5,7-trimethyl-2,3-dihydro-1H-inden-1-one
1H-Inden-1-one, 2,3-dihydro-6-(2-hydroxyethyl)-2,5,7-trimethyl-
6-(2-Hydroxyethyl)-2,5,7-trimethyl-1-indanone
Pterosin B

Biological Activity

[Description]:

Pterosin B, a indanone found in bracken fern (Pteridium aquilinum), is an inhibitor of salt-inducible kinase 3 (Sik3) signaling. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> Salt-inducible Kinase (SIK)

[Target]

SIK3

[References]

[1]. Hannah R.Dexter, et al. A concise stereoselective synthesis of pterosin B. Tetrahedron Letters, Volume 59, Issue 49, 5 December 2018, Pages 4323-4325.

[2]. Yahara Y, et al. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Nat Commun. 2016 Mar 24;7:10959.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
396.5±41.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₈O₂

[ Molecular Weight ]:
218.292

[ Flash Point ]:
169.3±20.2 °C

[ Exact Mass ]:
218.130676

[ PSA ]:
37.30000

[ LogP ]:
2.65

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.560

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK7537730

CHEMICAL NAME :: 1-Indanone, 6-(2-hydroxyethyl)-2,5,7-trimethyl-, (-)-

CAS REGISTRY NUMBER :: 34175-96-7

LAST UPDATED :: 198703

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C14-H18-O2

MOLECULAR WEIGHT :: 218.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 100 mg/L

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 31,829,1975

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914400090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914400090

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%