Chelerythrine

Names

[ Name ]:
Chelerythrine

[Synonym ]:
[1,3]Benzodioxolo[5,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl-
1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium
Cheleritrine
MFCD00060717
Chelerythrine
Chelerythrin-Kation
Chelerythrin
Chelerythrine chloride
1,2-Dimethoxy-12-methyl[1,3]dioxolo[4,5]benzo[1,2-c]phenanthridin-12-ium
Broussonpapyrine
Chelerythrin chlorid
EINECS 251-930-0

Biological Activity

[Description]:

Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM[1]. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity[2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

Signaling Pathways >> TGF-beta/Smad >> PKC

[Target]

PKC:0.7 μM (IC50)

[References]

[1]. Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9.

[2]. Shi B, et al. Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats. Life Sci. 2019 Jan 1;216:85-91.

Chemical & Physical Properties

[ Melting Point ]:
195-205ºC

[ Molecular Formula ]:
C₂₁H₁₈ClNO₄

[ Molecular Weight ]:
348.371

[ Exact Mass ]:
348.123047

[ PSA ]:
40.80000

[ LogP ]:
0.72060

[ Storage condition ]:
Desiccate at -20°C

Safety Information

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S36/37

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%