(4S,5R)-4-Hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one

Names

[ Name ]:
(4S,5R)-4-Hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one

[Synonym ]:
2-deoxy-D-erythro-pentono-1,5-lactone
(4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-one
2-deoxy-D-ribonolactone
2-Deoxy-ribono-1,4-lactone
Deoxyribonolactone
2-Deoxyribonolactone
2-Deoxy-D-ribono-1,4-lactone
2-Deoxy-D-ribonic-1,4-lactone

Chemical & Physical Properties

[ Density]:
1.438g/cm3

[ Boiling Point ]:
395.3ºC at 760mmHg

[ Molecular Formula ]:
C₅H₈O₄

[ Molecular Weight ]:
132.11500

[ Flash Point ]:
179.1ºC

[ Exact Mass ]:
132.04200

[ PSA ]:
66.76000

[ Index of Refraction ]:
1.521

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Reduced repair capacity of a DNA clustered damage site comprised of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 2-deoxyribonolactone results in an increased mutagenic potential of these lesions.

Mutat. Res. Fundam. Mol. Mech. Mutagen. 762 , 32-9, (2014)

A signature of ionizing radiation is the induction of DNA clustered damaged sites. Non-double strand break (DSB) clustered damage has been shown to compromise the base excision repair pathway, extendi...

Analysis of base excision DNA repair of the oxidative lesion 2-deoxyribonolactone and the formation of DNA-protein cross-links.

Meth. Enzymol. 408 , 48-64, (2006)

DNA base lesions arising from oxidation or alkylation are processed primarily by the base excision repair pathway (BER). The damaged bases are excised by DNA N-glycosylases, which generate apurinic/ap...

Histone-catalyzed cleavage of nucleosomal DNA containing 2-deoxyribonolactone.

J. Am. Chem. Soc. 134(19) , 8090-3, (2012)

Oxidized abasic sites such as 2-deoxyribonolactone (L) are produced in DNA by a variety of oxidizing agents, including potent cytotoxic antitumor natural products. 2-Deoxyribonolactone is labile under...