Betamipron

Names

[ Name ]:
Betamipron

[Synonym ]:
3-Benzamidopropanoic acid
MFCD00037293
Benzoyl-β-alanine
3-benzamidopropionic acid
Betamipron
3-(Benzoylamino)propionic acid

Biological Activity

[Description]:

Betamipron is a chemical compound which is used together with Panipenem to inhibit Panipenem uptake into the renal tubule and prevent nephrotoxicity.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.227 g/cm3

[ Boiling Point ]:
469.2ºC at 760 mmHg

[ Melting Point ]:
132 °C

[ Molecular Formula ]:
C₁₀H₁₁NO₃

[ Molecular Weight ]:
193.19900

[ Flash Point ]:
237.6ºC

[ Exact Mass ]:
193.07400

[ PSA ]:
66.40000

[ LogP ]:
1.28200

[ Index of Refraction ]:
1.557

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY3272500

CHEMICAL NAME :: beta-Alanine, N-benzoyl-

CAS REGISTRY NUMBER :: 3440-28-6

BEILSTEIN REFERENCE NO. :: 2212769

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H11-N-O3

MOLECULAR WEIGHT :: 193.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3496 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 39(Suppl 3),140,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36 gm/kg/90D-C

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - changes in sodium

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 39(Suppl 3),157,1991

Safety Information

[ WGK Germany ]:
3

[ RTECS ]:
AY3272500

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Reaction of Pseudomonas fluorescens kynureninase with beta-benzoyl-L-alanine: detection of a new reaction intermediate and a change in rate-determining step.

Biochemistry 43(11) , 3230-7, (2004)

Beta-benzoyl-DL-alanine was synthesized from alpha-bromoacetophenone and diethyl acetamidomalonate. The racemic amino acid was resolved by carboxypeptidase A-catalyzed hydrolysis of the N-trifluoroace...

Thermodynamic quantitative structure-activity relationship analysis for enzyme-ligand interactions in aqueous phosphate buffer and organic solvent.

Bioorg. Med. Chem. 9(8) , 1951-5, (2001)

Thermodynamic quantitative structure-activity relationships (QSAR) for chymotrypsin-ligand binding is developed, and the results are compared for the effects of organic solvent on the substrate specif...

Nephroprotective effect of betamipron on a new carbapenem, DA-1131, in rabbits.

Biopharm. Drug Dispos. 20(3) , 125-9, (1999)

The nephroprotective effect of betamipron (200 mg/kg) was evaluated after intravenous administration of a high dose of DA-1131 (200 mg/kg) to rabbits. Extensive tubular necrosis was observed without b...