Prudomestin

Names

[ Name ]:
Prudomestin

[Synonym ]:
3,5,7-Trihydroxy-8-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-8-methoxy-2-(4-methoxyphenyl)-
3,5,7-Trihydroxy-6,8-dimethoxyflavone
3,5,7-trihydroxy-8,4'-dimethoxyflavone
Predomestin
3,5,7-Trihydroxy-6,8-dimethoxy-flavon
3,5,7-Trihydroxy-8,4'-dimethoxy-flavon
Prudomestin
3,5,7-trihydroxy-4',8-dimethoxyflavone
3,5,7-trihydroxy-6,8-dimethoxy-2-phenyl-chromen-4-one
4H-1-Benzopyran-4-one,3,5,7-trihydroxy-6,8-dimethoxy-2-phenyl

Biological Activity

[Description]:

Prudomestin, isolated from the heartwood of Prunus domestica, shows potent xanthine oxidase (XO) inhibitory activity (IC50≈6 µM)[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase

[References]

[1]. Nooreen Z, et al. Characterization and evaluation of bioactive polyphenolic constituents from Zanthoxylum armatum DC., a traditionally used plant. Biomed Pharmacother. 2017 May;89:366-375.

[2]. Ranjana, et al. Standardization and xanthine oxidase inhibitory potential of Zanthoxylum armatum fruits. J Ethnopharmacol. 2019 Feb 10;230:1-8.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
568.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₄O₇

[ Molecular Weight ]:
330.289

[ Flash Point ]:
212.2±23.6 °C

[ Exact Mass ]:
330.073944

[ PSA ]:
109.36000

[ LogP ]:
2.01

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.681

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%