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EMI48

Names

[ CAS No. ]:
34564-13-1

[ Name ]:
EMI48

[Synonym ]:
EINECS 252-093-4
disperse yellow 184

Biological Activity

[Description]:

EMI48, the derivative of EMI1, displays greater potency toward mutant EGFR than EMI1. EMI48 inhibits EGFR triple mutants[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFRL858R/T790M/C797S

EGFRdel19 T790M C797S


[In Vitro]

EMI48 inhibits EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S. EMI48 can be used in the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC)[1].

[References]

[1]. Punit Saraon , et al. A Drug Discovery Platform to Identify Compounds That Inhibit EGFR Triple Mutants.Nat Chem Biol. 2020 May;16(5):577-586.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H20N2O3

[ Molecular Weight ]:
348.39500

[ Exact Mass ]:
348.14700

[ PSA ]:
59.48000

[ LogP ]:
4.75580

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream