2,4'-PCB

Names

[ Name ]:
2,4'-PCB

[Synonym ]:
1-chloro-2-(4-chlorophenyl)benzene
2,4'-Dichlorobiphenyl
PCB 8
2,4'-dichlorobipenyl
1,1'-Biphenyl,2,4'-dichloro
2,4'-Dichloro-1,1'-biphenyl
2,4'-chlorobiphenyl
2,4'-PCB
Biphenyl,2,4'-dichloro
1,1'-Biphenyl, 2,4'-dichloro-

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
303.3±17.0 °C at 760 mmHg

[ Melting Point ]:
46°C

[ Molecular Formula ]:
C₁₂H₈Cl₂

[ Molecular Weight ]:
223.098

[ Flash Point ]:
133.6±14.5 °C

[ Exact Mass ]:
222.000305

[ LogP ]:
5.02

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.594

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DV3905000

CHEMICAL NAME :: Biphenyl, 2,4'-dichloro-

CAS REGISTRY NUMBER :: 34883-43-7

BEILSTEIN REFERENCE NO. :: 1946417

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C12-H8-Cl2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7860 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 24,173,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg/3D-I

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 33,94,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 25 mg/kg/20D-I

TOXIC EFFECTS :: Immunological Including Allergic - decrease in humoral immune response

REFERENCE :: JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984- Volume(issue)/page/year: 9,283,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 25 mg/kg/20D-I

TOXIC EFFECTS :: Liver - other changes

REFERENCE :: JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984- Volume(issue)/page/year: 12,17,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 20 mg/kg/20D-I

TOXIC EFFECTS :: Liver - changes in liver weight Immunological Including Allergic - decrease in humoral immune response Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984- Volume(issue)/page/year: 9,283,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 5 mg/kg/20D-I

TOXIC EFFECTS :: Liver - other changes

REFERENCE :: JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984- Volume(issue)/page/year: 12,17,1993

Safety Information

[ Symbol ]:

GHS08, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H373-H410

[ Precautionary Statements ]:
P260

[ Hazard Codes ]:
N: Dangerous for the environment;

[ Risk Phrases ]:
33-50/53

[ Safety Phrases ]:
35-60-61

[ RIDADR ]:
UN 3432 9/PG 2

[ RTECS ]:
DV3905000

[ HS Code ]:
2903999010

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2903999010

[ Summary ]:
2903999010 2,3,3',4,5,6-hexachloro-1,1'-biphenyl。supervision conditions:89(articles on the list of prohibited export goods,articles on the list of prohibited import goods)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:5.5%。general tariff:30.0%

Articles

Metabolism of dichlorobiphenyls by hepatic microsomal cytochrome P-450.

Biochem. Pharmacol. 30(6) , 577-88, (1981)

Microbial growth on dichlorobiphenyls chlorinated on both rings as a sole carbon and energy source.

Appl. Environ. Microbiol. 67(4) , 1953-5, (2001)

We have isolated bacterial strains capable of aerobic growth on ortho-substituted dichlorobiphenyls as sole carbon and energy sources. During growth on 2,2'-dichlorobiphenyl and 2,4'-dichlorobiphenyl ...

Temperature-dependent biotransformation of 2,4'-dichlorobiphenyl by psychrotolerant Hydrogenophaga strain IA3-A: higher temperatures prevent excess accumulation of problematic meta-cleavage products.

Lett. Appl. Microbiol. 44(4) , 447-53, (2007)

The present work investigates the possibility that temperature could regulate the pattern of transformation of 2,4'-chlorobiphenyl (2,4'-CB) by psychrotolerant Hydrogenophaga sp. IA3-A.Transformation ...