Bunitrolol

Names

[ Name ]:
Bunitrolol

[Synonym ]:
Bunitrolol
Stresson
Bunitrolol HCl
2-Nitrilo-N-tert-butylphenoxypropanolamine
KO-1366

Biological Activity

[Description]:

Bunitrolol is a beta-adrenergic antagonist. Bunitrolol has intrinsic sympathomimetic activity. Bunitrolol can be used for the research of ischemic myocardium[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[References]

[1]. Chiba K, et al. Effects of bunitrolol on ischemic myocardial energy metabolism in dogs. J Pharm Sci. 1993 Apr;82(4):384-8.

Chemical & Physical Properties

[ Density]:
1.09g/cm3

[ Boiling Point ]:
414.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₂₀N₂O₂

[ Molecular Weight ]:
248.32

[ Flash Point ]:
204.3ºC

[ Exact Mass ]:
248.15200

[ PSA ]:
65.28000

[ LogP ]:
2.07698

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DI2530000

CHEMICAL NAME :: Benzonitrile, o-(3-(tert-butylamino)-2-hydroxypropoxy)-

CAS REGISTRY NUMBER :: 34915-68-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H20-N2-O2

MOLECULAR WEIGHT :: 248.36

WISWESSER LINE NOTATION :: NCR BO1YQ1MX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 46 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 17,341,1972

Safety Information

[ HS Code ]:
2926909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%