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Bifeprunox Mesylate

Names

[ CAS No. ]:
350992-13-1

[ Name ]:
Bifeprunox Mesylate

[Synonym ]:
Bifeprunox mesilate
2(3H)-Benzoxazolone, 7-[4-([1,1'-biphenyl]-3-ylmethyl)-1-piperazinyl]-, methanesulfonate (1:1)
7-[4-([1,1'-Biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate
7-[4-(3-Biphenylylmethyl)-1-piperazinyl]-1,3-benzoxazol-2(3H)-one methanesulfonate (1:1)
(7-[4-([1,1-Biphenyl]-3-ylmethyl)-1-piperazinyl])
Bifeprunox Mesylate
7-[4-([1,1'-Biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone Mesylate

Biological Activity

[Description]:

Bifeprunox mesylate is a potent dopamine D2-like and 5-HT1A receptor partial agonist with pKis of 7.19 and 8.83 for cortex 5-HT1A and striatum D2, and a pEC50 of 6.37 for hippocampus 5-HT1A, respectively. Bifeprunox mesylate is an antipsychotic for the research of schizophrenia[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Newman-Tancredi A, et al. Novel antipsychotics activate recombinant human and native rat serotonin 5-HT1A receptors: affinity, efficacy and potential implications for treatment of schizophrenia. Int J Neuropsychopharmacol. 2005 Sep;8(3):341-56.  

[2]. Bruins Slot LA, et al. Effects of antipsychotics and reference monoaminergic ligands on marble burying behavior in mice. Behav Pharmacol. 2008 Mar;19(2):145-52.  

[3]. Di Clemente A, et al. Bifeprunox: a partial agonist at dopamine D2 and serotonin 1A receptors, influences nicotine-seeking behaviour in response to drug-associated stimuli in rats. Addict Biol. 2012 Mar;17(2):274-86.  

Chemical & Physical Properties

[ Molecular Formula ]:
C25H27N3O5S

[ Molecular Weight ]:
481.56

[ Exact Mass ]:
481.16700

[ PSA ]:
115.23000

[ LogP ]:
4.69800

Related Compounds