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Necrostatin-7

Names

[ CAS No. ]:
351062-08-3

[ Name ]:
Necrostatin-7

[Synonym ]:
(5Z)-5-{[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene}-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one
HMS621M06
necrotatin-7
Necrostatin-7
Nec-7
5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone Nec-7
4-Thiazolidinone, 5-[[3-(4-fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-, (5Z)-

Biological Activity

[Description]:

Necrotatin-7 (Nec-7) is a potent necroptosis inhibitor with an EC50 of 10.6 μM. Necrotatin-7 does not inhibit recombinant RIP1 kinase[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Weihong Zheng, et al. Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4932-5.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
613.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H10FN5OS2

[ Molecular Weight ]:
371.412

[ Flash Point ]:
324.8±34.3 °C

[ Exact Mass ]:
371.031067

[ PSA ]:
139.27000

[ LogP ]:
2.73

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.805

MSDS

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Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds