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(Ala1)-PAR-4 (1-6) amide (mouse) trifluoroacetate salt

Names

[ CAS No. ]:
352017-71-1

[ Name ]:
(Ala1)-PAR-4 (1-6) amide (mouse) trifluoroacetate salt

[Synonym ]:
Proteinase activated receptor 4 amide,mouse
PAR-4 AGONIST AMIDE
ALA-TYR-PRO-GLY-LYS-PHE-NH2
AYPGKFAMIDE
PROTEASE-ACTIVATED RECEPTOR-4 AGONIST AMIDE
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
AYPGKF-NH2
(Ala1)-PAR-4 (1-6) amide (mouse)
PAR-4 Agonist Peptide, amide

Biological Activity

[Description]:

PAR-4 Agonist Peptide, amide is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR)
Peptides
Research Areas >> Inflammation/Immunology

[Target]

PAR-4[1]


[In Vivo]

Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05) [1].

[Animal admin]

Mice[1] SCID mice Male SCID mice and their BALB/cBy controls are operated as C57BL/6J mice, and on the 4th postoperative day mice receive intracolonically (IC) infusion of 100 μg PAR-4-AP or vehicle. Visceral pain measurements started 1 h following the end of infusion[1].

[References]

[1]. Annaházi A, et al. Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activatedfeed-back loop in visceral inflammatory pain. Neurogastroenterol Motil. 2012 Jan;24(1):76-85, e13.


[Related Small Molecules]

TRAP-6 | AZ 3451 | AC-55541 | SLIGKV-NH2 | PAR-4 (1-6) amide (mouse) trifluoroacetate salt | TFLLR-NH2 TFA | BMS-986120 | SLIGRL-NH2 2TFA | TRAP-5 trifluoroacetate salt

Chemical & Physical Properties

[ Molecular Formula ]:
C34H48N8O7

[ Molecular Weight ]:
680.79400

[ Exact Mass ]:
680.36500

[ PSA ]:
252.07000

[ LogP ]:
2.30290

[ Storage condition ]:
2-8℃

Safety Information

[ Safety Phrases ]:
S22-S24/25

Related Compounds