THP-CH3-ethyl propionate

Names

[ CAS No. ]:
3539-40-0

[ Name ]:
THP-CH3-ethyl propionate

[Synonym ]:
Tetrahydropyranylethyllactat

Biological Activity

[Description]:

THP-CH3-ethyl propionate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.05g/cm3

[ Boiling Point ]:
292.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₈O₄

[ Molecular Weight ]:
202.24800

[ Flash Point ]:
125.6ºC

[ Exact Mass ]:
202.12100

[ PSA ]:
44.76000

[ LogP ]:
1.48120

[ Index of Refraction ]:
1.448

THP-CH3-ethyl propionate

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds