<Suppliers Price>

Ac-Nle-Pro-Nle-Asp-AMC

Names

[ CAS No. ]:
355140-49-7

[ Name ]:
Ac-Nle-Pro-Nle-Asp-AMC

[Synonym ]:
(3S)-4-Hydroxy-3-({(2S)-1-hydroxy-2-[(hydroxy{(2S)-1-[N-(1-hydroxyethylidene)-L-norleucyl]-2-pyrrolidinyl}methylene)amino]hexylidene}amino)-4-[(4-methyl-2-oxo-2H-chromen-7-yl)imino]butanoic acid
Butanoic acid, 4-hydroxy-3-[[(2S)-1-hydroxy-2-[[hydroxy[(2S)-1-[(2S)-2-[(1-hydroxyethylidene)amino]-1-oxohexyl]-2-pyrrolidinyl]methylene]amino]hexylidene]amino]-4-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)imino]-, (3S)-

Biological Activity

[Description]:

Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis[1][2][3].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

[References]

[1]. Dunlop RA, et al. The impact of specific oxidized amino acids on protein turnover in J774 cells. Biochem J. 2008 Feb 15;410(1):131-40.

[2]. Kirk-Ballard H, et al. An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes. PLoS One. 2013;8(2):e57112.

[3]. Pakavathkumar P, et al. Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine. Sci Rep. 2015 Sep 24;5:13730.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
902.2±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C33H45N5O9

[ Molecular Weight ]:
655.739

[ Flash Point ]:
499.4±37.1 °C

[ Exact Mass ]:
655.321716

[ LogP ]:
6.08

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.617

Related Compounds