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CP-20961

Names

[ CAS No. ]:
35607-20-6

[ Name ]:
CP-20961

[Synonym ]:
cp-20,961
avridine

Biological Activity

[Description]:

CP-20961 is a potent synthetic non-immunogenic adjuvant that induces arthritis[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vivo]

Avridine-induced arthritis is severe and long lasting in LEW and DA rats[2]. CP-20961 (10 mg/kg, i.v., once either 24, 48, or 72 hours post-burn) had no effect on survival after challenge with P. aeruginosa 96 hours post-burn[3]. Animal Model: Female, Hartley-derived guinea pigs, weighing 350 to 400 g[3]. Dosage: 10 mg/kg. Administration: IV once either 24, 48, or 72 hours post-burn. Result: Had no effect on survival after challenge with P. aeruginosa 96 hours post-burn.

[References]

[1]. Brun JG, et al. Effects of calprotectin in avridine-induced arthritis. APMIS. 1995 Mar;103(3):233-40.

[2]. Vingsbo C, et al. Avridine-induced arthritis in rats; a T cell-dependent chronic disease influenced both by MHC genes and by non-MHC genes. Clin Exp Immunol. 1995 Mar;99(3):359-63.

[3]. Stinnett JD, et al. Synthetic immunomodulators for prevention of fatal infections in a burned guinea pig model. Ann Surg. 1983 Jul;198(1):53-7.

Chemical & Physical Properties

[ Density]:
0.892g/cm3

[ Boiling Point ]:
717.6ºC at 760mmHg

[ Molecular Formula ]:
C43H90N2O2

[ Molecular Weight ]:
667.18700

[ Flash Point ]:
294.3ºC

[ Exact Mass ]:
666.70000

[ PSA ]:
46.94000

[ LogP ]:
12.48810

[ Index of Refraction ]:
1.478

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KK7243000
CHEMICAL NAME :
Ethanol, 2,2'-((3-(dioctadecylamino)propyl)imino)bis-
CAS REGISTRY NUMBER :
35607-20-6
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C43-H90-N2-O2
MOLECULAR WEIGHT :
667.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 3,498,1973

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
KK7243000

[ HS Code ]:
2922199090

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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