1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane

Names

[ Name ]:
1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane

[Synonym ]:
MFCD08669605

Biological Activity

[Description]:

1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.355g/cm3

[ Boiling Point ]:
710.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₂₈O₁₂

[ Molecular Weight ]:
424.39700

[ Flash Point ]:
248.8ºC

[ Exact Mass ]:
424.15800

[ PSA ]:
186.12000

[ Index of Refraction ]:
1.512