Seletracetam

Names

[ Name ]:
Seletracetam

[Synonym ]:
UNII-RFR2CH3QZK
Seletracetam
Seletracetam (USAN/INN)

Biological Activity

[Description]:

Seletracetam (Ucb 44212) is an analog of the antiepileptic agent Levetiracetam. Seletracetam is a small molecule SV2A modulator for the research of epilepsy[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

SV2A[1]

[In Vitro]

Seletracetam decreases seizure activity in a number of epilepsy models and binds to the synaptic vesicle protein SV2A[2]. Seletracetam decreases synaptic responses in a time-, frequency- and concentration-dependent manner[2]. Seletracetam modifies rates of presynaptic release[2]. Seletracetam inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro[2].

[References]

[1]. Pollard JR, et al. Seletracetam, a small molecule SV2A modulator for the treatment of epilepsy. Curr Opin Investig Drugs. 2008 Jan;9(1):101-7.

[2]. Yang X, et al. Seletracetam enhances short term depression in vitro. Epilepsy Res. 2015 Nov;117:17-22.

[3]. Martella G, et al. Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro. Epilepsia. 2009 Apr;50(4):702-10.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₄F₂N₂O₂

[ Molecular Weight ]:
232.22700

[ Exact Mass ]:
232.10200

[ PSA ]:
64.39000

[ LogP ]:
1.96680

Safety Information

[ HS Code ]:
2933790090

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%