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7,8,9,9-Tetradehydroisolariciresinol

Names

[ CAS No. ]:
357645-16-0

[ Name ]:
7,8,9,9-Tetradehydroisolariciresinol

[Synonym ]:
2-Naphthalenecarboxaldehyde, 3,4-dihydro-6-hydroxy-4-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-, (3R,4S)-
(3R,4S)-6-Hydroxy-4-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-3,4-dihydro-2-naphthalenecarbaldehyde

Biological Activity

[Description]:

Vitexin B-1 is an inhibitor of Bcl-2 and the agonist of Caspase. Vitexin B-1 has cytotoxic effect and induces apoptosis in MCF-7, ZR-75-1, MDA-MB-231, and COC1 cells with IC50s of 3.2, 2.1, 1.8 and 0.39 μM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family
Research Areas >> Cancer

[References]

[1]. Zhou Y, et al. Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth. Clin Cancer Res. 2009 Aug 15;15(16):5161-9.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
587.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H20O6

[ Molecular Weight ]:
356.369

[ Flash Point ]:
211.0±23.6 °C

[ Exact Mass ]:
356.125977

[ PSA ]:
96.22000

[ LogP ]:
2.59

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.664

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds