Muscimol hydrochloride

Muscimol (Agarin; Agarine) hydrochloride is an isoxazole with psychoactive activity. Muscimol hydrochloride is also a selective agonist of the inhibitory neurotransmitter, GABA ionotropic receptors. Muscimol hydrochloride can be isolated from from Amanita muscaria and related mushrooms. All in all, Muscimol is a potent GABAA receptors agonist (EC50=0.2 μM), a partial GABACreceptors agonist, and an inactive GABAB receptors agonist. Muscimol hydrochloride has calming, anti-anxiety and hallucinatory effects[1].

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

EC50: 0.2 μM (GABACreceptors)[1]

Muscimol 影响前额叶皮层的功能，并且在注射到腹侧前额叶皮层后（1μL，5μg/μL；前额叶皮层输注），损害猴子在计数任务中的表现，但在注射到背侧前额叶皮层后没有影响[2]。 Muscimol 影响前扣带皮层 (ACC) 的微量调节，并且在 10 秒微量组中（62.5 或 125 µg/侧）对抑制噪声刺激没有影响[3]。 Animal Model: Female rhesus monkeys (Macaca mulatta) (5 kg and 5.5 kg)[2] Dosage: 1 μL, 5 μg/μL Administration: Implanted drug delivery tubes and infusion; single dose Result: Increased the error types and reaction time during the counting task.

[1]. Johnston GA. Muscimol as an ionotropic GABA receptor agonist. Neurochem Res. 2014 Oct;39(10):1942-7.  

[2]. Sun W, et al. Muscimol-induced inactivation of the ventral prefrontal cortex impairs counting performance in rhesus monkeys. Sci Prog. 2022 Oct-Dec;105(4):368504221141660.  

[3]. Pezze MA, et al. Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat. J Psychopharmacol. 2020 Dec;34(12):1457-1460.