Bumadizone

Names

[ Name ]:
Bumadizone

[Synonym ]:
Butyramide,N-sec-butyl
(+-)-Buttersaeure-sec-butylamid
2-[(1,2-Diphenylhydrazino)carbonyl]hexanoic acid
Butanamide,N-(1-methylpropyl)
N-(2-Carboxy-hexanoyl)-hydrazobenzol
N-s-Butyl-butyramide
N-sec-butyl-butyramide
N-(2-carboxycaproyl)hydrazobenzene
N-(2-BUTYL)BUTANAMIDE
Bumadizon (14C)
Butylmalonsaeure-N,N'-diphenylmonohydrazid
(+-)-Butylmalonsaeure-mono-<N.N'-diphenyl-hydrazid>

Biological Activity

[Description]:

Bumadizone is a non-steroidal anti-inflammatory drug (NSAID) and can relieve pain[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the chronic inflammatoryconditions.

[References]

[1]. Samia A Nour, et al. Bumadizone calcium dihydrate microspheres compressed tablets for colon targeting: formulation, optimization and in vivo evaluation in rabbits. Drug Deliv. 2015 May;22(3):286-97.

Chemical & Physical Properties

[ Density]:
1.227g/cm3

[ Boiling Point ]:
487.4ºC at 760mmHg

[ Molecular Formula ]:
C₁₉H₂₂N₂O₃

[ Molecular Weight ]:
326.39000

[ Flash Point ]:
248.6ºC

[ Exact Mass ]:
326.16300

[ PSA ]:
69.64000

[ LogP ]:
4.01070

[ Index of Refraction ]:
1.628

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO0623000

CHEMICAL NAME :: Malonic acid, butyl-, mono(1,2-diphenylhydrazide)

CAS REGISTRY NUMBER :: 3583-64-0

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H22-N2-O3

MOLECULAR WEIGHT :: 326.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 67,337,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 67,337,1971

Safety Information

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%