SIBA

Names

[ Name ]:
SIBA

[Synonym ]:
adenosine,5'-s-(2-methylpropyl)-5'-thio-
5-isobutylthio-5-deoxyadenosine
SIBA

Biological Activity

[Description]:

SIBA selectively inhibits spermine synthase, IC50=8 uM.IC50 value: 8 uMTarget: spermine synthaseSIBA is a powerful antiproliferative drug. SIBA has been reported to inhibit cell transformation induced by oncogenic RNA or DNA viruses, the growth of transformed mouse mammary cells, the mitogen-stimulated blastogenesis of lymphocytes and the capping of herpes virus mRNA 161. It has also been demonstrated that an antimalarial activity is exerted by SIBA against Plasmodium falciparum in cultures.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[References]

[1]. Carteni-Farina M, et al. Studies on the metabolism of 5'-isobutylthioadenosine (SIBA): phosphorolytic cleavage by methylthioadenosinephosphorylase. FEBS Lett. 1979 Aug 15;104(2):266-270.

[2]. Lawrence F, et al. Effect of 5'-deoxy-5'-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chick embryofibroblasts. Biochem J. 1982 Jun 15;204(3):853-859.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₂₁N₅O₃S

[ Molecular Weight ]:
339.41300

[ Exact Mass ]:
339.13700

[ PSA ]:
144.61000

[ LogP ]:
0.99810

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%