CAY10499

Names

[ Name ]:
CAY10499

[Synonym ]:
Carbamic acid, N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]-, phenylmethyl ester
Benzyl [4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]carbamate

Biological Activity

[Description]:

MAGL-IN-5 is a non-selective lipase inhibitor with IC50 values of 144, 90, and 14 nM for human recombinant monoacylglycerol lipase(MAGL),hormone sensitive lipase(HSL), and fatty acid amide hydrolase(FAAH) respectively[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL

Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH

Research Areas >> Metabolic Disease

Signaling Pathways >> Neuronal Signaling >> FAAH

[References]

[1]. Muccioli GG, et al. CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay. Chembiochem. 2008 Nov 3;9(16):2704-10.

[2]. Granchi C, et al. 4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors. J Enzyme Inhib Med Chem. 2016;31(1):137-46.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₁₈H₁₇N₃O₅

[ Molecular Weight ]:
355.345

[ Exact Mass ]:
355.116821

[ PSA ]:
95.59000

[ LogP ]:
1.97

[ Index of Refraction ]:
1.610