Hydracarbazine

Names

[ Name ]:
Hydracarbazine

[Synonym ]:
3-Hydrazino-6-carbamoyl-pyridazin
6-hydrazinopyridazine-3-carboxamide
6-Hydrazino-pyridazin-3-carbonsaeure-amid
Hidracarbazina
6-hydrazino-pyridazine-3-carboxylic acid amide
UNII-6CTK2FB9QM
TH-2151
Hydracarbazine
Hydracarbazinum
Hydracarbazine [INN:DCF]
3-carbamoyl-6-pyridazinylhydrazine

Biological Activity

[Description]:

Hydracarbazine is a pyridazine. Hydracarbazine can effectively lower blood pressure, it can be used for the research of high blood pressure[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[In Vivo]

Hydracarbazine (1-4 mg/kg; i.v. once) induced in the dog, cat and rabbit hypotension by peripheral vasodilation, showed no inhibitory action on vasomotor centers and decreased the hypertensive effects of adrenaline, noradrenaline, 5-hydroxytryptamine, pituitrin, and splanchnic nerve stimulation[1]. Hydracarbazine (15-18 mg/kg; p.o. once daily) prevents the increased blood pressure and heart rate, reduces the renal histol and reduces the hypertensive syndrome with a combination of pempidine in high arterial pressure rats[2].

[References]

[1]. Schmitt H, et al. Pharmacological study of a new hypotensor with a long duration of action: 1-hydrazino-4-carboxamidopyridazine (1325). Journal de Physiologie. 1992 52:525-36.

[2]. Ghaye-Roquet J, et al. [Prevention of experimental hypertension in the rat by prolonged administration of a combination of antihypertensive agents]. Arch Int Pharmacodyn Ther. 1967 Mar;166(1):65-78.

Chemical & Physical Properties

[ Density]:
1.513g/cm3

[ Boiling Point ]:
549.1ºC at 760mmHg

[ Molecular Formula ]:
C₅H₇N₅O

[ Molecular Weight ]:
153.14200

[ Flash Point ]:
285.9ºC

[ Exact Mass ]:
153.06500

[ PSA ]:
110.15000

[ Index of Refraction ]:
1.717

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%