4-Piperidone, 1-hydroxy-2,2,6,6-tetramethyl-

Names

[ Name ]:
4-Piperidone, 1-hydroxy-2,2,6,6-tetramethyl-

[Synonym ]:
1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-one
1-Hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine
4-oxo-TEMPO-H
4-Piperidinone,1-hydroxy-2,2,6,6-tetramethyl
1-Hydroxy-2,2,6,6-tetramethyl-piperidin-4-on
2,2,6,6-tetramethyl-4-oxo-1-piperidinyloxy
Tempone-H
N-hydroxy-4-oxo-2,2,6,6-tetramethylpiperidine
1-Hydroxy-2,2,6,6-tetramethyl-4-piperidinone

Biological Activity

[Description]:

Tempone-H may be used as a spin trap in chemical and biological systems to quantify peroxynitrite and superoxide radical formation. Ferric and cupric ions are effective oxidants of Tempone-H[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

Using TEMPONE-H the obtained sensitivity in the detection of peroxynitrite or superoxide radicals is about 10-fold higher than using the spin traps DMPO or TMIO[1].

[References]

[1]. Dikalov S, et al. Quantification of peroxynitrite, superoxide, and peroxyl radicals by a new spin trap hydroxylamine 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine. Biochem Biophys Res Commun. 1997 Jan 3;230(1):54-7.

[2]. Dikalov SI, et al. Amyloid beta peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides. J Biol Chem. 1999 Apr 2;274(14):9392-9.

Chemical & Physical Properties

[ Density]:
1.02g/cm3

[ Boiling Point ]:
257.5ºC at 760mmHg

[ Molecular Formula ]:
C₉H₁₇NO₂

[ Molecular Weight ]:
171.23700

[ Flash Point ]:
109.5ºC

[ Exact Mass ]:
171.12600

[ PSA ]:
40.54000

[ LogP ]:
1.53560

[ Storage condition ]:
-20°C

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%