4-Hydroxy-2,5-dimethylfuran-3(2H)-one
Names
[ CAS No. ]:
3658-77-3
[ Name ]:
4-Hydroxy-2,5-dimethylfuran-3(2H)-one
[Synonym ]:
2,5-DiMethyl-4-hydroxy-3(2H)-furanone
CARMELAN
FEMA 3174
4-hydroxy-2,5-dimethyl-3-oxo-2H-furan
Pineapple ketone
4-Hydroxy-2,5-dimethylfuran-2(3H)-one
EINECS 222-908-8
T5OJ B1 CQ DQ E1
4-Hydroxy-2,5-dimethyl-3-furanone
Strawberry furanone
4-Hydroxy-2,5-dimethyl-3(2H)furanone
2,5-dimethyl-4-hydroxy-2H-furan-3-one
Dimethylhydroxy furanone
2,5-Dimethyl-4-hydroxy-3(2H)-furanone,Furaneol,Strawberry furanone
2,5-dimethyl-4-hydroxy-2,3-dihydrofuran-3-one
Alletone
Furaneol
4-Hydroxy-2,5-dimethylfuran-3(2H)-one
2,4-DIMETHYLBENZENEBORONIC ACID
T5O CV BHJ B1 DQ E1
4-oxo-3-hydroxy-2,5-dimethyl-4,5-dihydrofuran
HDMF
RI-2024
3(2H)-Furanone, 4-hydroxy-2,5-dimethyl-
4-Hydroxy-2,5-dimethyl-3(2H)-furanone
MFCD00010706
T5VV DOTJ C1 E1
COE 536
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
215.5±40.0 °C at 760 mmHg
[ Melting Point ]:
73-77 °C(lit.)
[ Molecular Formula ]:
C6H8O3
[ Molecular Weight ]:
128.126
[ Flash Point ]:
90.5±20.8 °C
[ Exact Mass ]:
128.047348
[ PSA ]:
46.53000
[ LogP ]:
0.34
[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C
[ Index of Refraction ]:
1.513
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LU3990000
- CHEMICAL NAME :
- 3(2H)-Furanone, 2,5-dimethyl-4-hydroxy-
- CAS REGISTRY NUMBER :
- 3658-77-3
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C6-H8-O3
- MOLECULAR WEIGHT :
- 128.14
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1608 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Sister chromatid exchange
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 232 mg/kg
- REFERENCE :
- CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known. Volume(issue)/page/year: 22,85,1988
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S36-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
LU3990000
[ HS Code ]:
2932190090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2932190090
[ Summary ]:
2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
Articles
Arch. Pediatr. Adolesc. Med. 157(10) , 1031, (2003)
Structural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone.
J. Biol. Chem. 288(23) , 16815-26, (2013)
The last step in the biosynthetic route to the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF) is catalyzed by Fragaria x ananassa enone oxidoreductase (FaEO), earlier puta...
Characterization of the key aroma compounds in soy sauce using approaches of molecular sensory science.J. Agric. Food Chem. 55(15) , 6262-9, (2007)
Application of aroma extract dilution analysis (AEDA) to the volatiles isolated from a commercial Japanese soy sauce revealed 30 odor-active compounds in the flavor dilution (FD) factor range of 8-409...