2-(4-FLUOROPHENYLAMINO)THIAZOLO[4,5-B]PYRIDINE-5,7-DIOL

Names

[ Name ]:
2-(4-FLUOROPHENYLAMINO)THIAZOLO[4,5-B]PYRIDINE-5,7-DIOL

[Synonym ]:
2-[(4-Fluorophenyl)amino]-7-hydroxy[1,3]thiazolo[4,5-b]pyridin-5(4H)-one
MFCD01242898
Thiazolo[4,5-b]pyridin-5(4H)-one, 2-[(4-fluorophenyl)amino]-7-hydroxy-

Biological Activity

[Description]:

STK683963 is a strong activator of cellular ATG4B activity. STK683963 can act as a mediator of redox-regulation of ATG4B in cells. STK683963 can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

[In Vitro]

STK683963 (0-50 μM) 在 24 小时后以剂量依赖性方式强烈上调荧光素酶释放报告基因[1]。 STK683963 强烈激活荧光素酶释放，这在 NAC 存在下被完全阻断[1]。

[References]

[1]. Niccolo Pengo, et al. Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells. Front Cell Dev Biol. 2018 Nov 1;6:148.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
554.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₈FN₃O₂S

[ Molecular Weight ]:
277.274

[ Flash Point ]:
289.0±32.9 °C

[ Exact Mass ]:
277.032135

[ LogP ]:
3.30

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.809