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3-hydroxy-9H-9-xanthenone

Names

[ CAS No. ]:
3722-51-8

[ Name ]:
3-hydroxy-9H-9-xanthenone

[Synonym ]:
MFCD06796485
3-hydroxy-9H-9-xanthenone
Sieber Linker; 3-Hydroxy-xanthen-9-one
3-hydroxyxanthen-9-one
3-Hydroxy-9H-xanthen-9-one
9H-Xanthen-9-one, 3-hydroxy-
Xanthen-9-one, 3-hydroxy-
Sieber Linker
Weinreb Linker

Biological Activity

[Description]:

3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one) is a xanthone compound, with . 3-Hydroxyxanthone inhibits NADPH-catalysed lipid peroxidation in human umbilical vein endothelial cells (HUVECs). 3-Hydroxyxanthone also inhibits TNF-alpha induced ICAM-1 expression[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Cytoskeleton >> Integrin

[References]

[1]. Madan B, et al. Xanthones as inhibitors of microsomal lipid peroxidation and TNF-alpha induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs). Bioorg Med Chem. 2002 Nov;10(11):3431-6.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
403.9±24.0 °C at 760 mmHg

[ Melting Point ]:
243 °C

[ Molecular Formula ]:
C13H8O3

[ Molecular Weight ]:
212.20

[ Flash Point ]:
162.9±16.4 °C

[ Exact Mass ]:
212.047348

[ PSA ]:
50.44000

[ LogP ]:
2.83

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.679

[ Storage condition ]:
Store at 0°C

MSDS

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Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S16-S26-S36/37/39-S37/39

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
29329900

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds