Sennoside D

Names

[ Name ]:
Sennoside D

[Synonym ]:
(9R,9'S)-5,5'-Bis(β-D-glucopyranosyloxy)-4,4'-dihydroxy-2'-(hydroxymethyl)-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2-carboxylic acid
[9,9'-Bianthracene]-2-carboxylic acid, 5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-2'-(hydroxymethyl)-10,10'-dioxo-, (9R,9'S)-
SennosideD

Biological Activity

[Description]:

Sennoside D is an anthraquinone glycoside, found in leaves and pods of Senna (Cassia angustifolia)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10(6):e0129422.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
1130.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₂H₄₀O₁₉

[ Molecular Weight ]:
848.756

[ Flash Point ]:
344.4±27.8 °C

[ Exact Mass ]:
848.216370

[ PSA ]:
330.89000

[ LogP ]:
0.68

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.758

[ Storage condition ]:
2-8°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Potentiating effect of sennoside C on purgative activity of sennoside A in mice.

Planta Med. 42(3) , 302-3, (1981)

The synergistic purgative action of aloe-emodin anthrone and rhein anthrone in mice: synergism in large intestinal propulsion and water secretion.

J. Pharm. Pharmacol. 49(1) , 22-5, (1997)

This study aimed to explore the mechanism involved in the synergistic purgative action of aloe-emodin anthrone and rhein anthrone, the active metabolites of sennoside C. Aloe-emodin anthrone and rhein...

Metabolic activation of sennoside C in mice: synergistic action of anthrones.

J. Pharm. Pharmacol. 44(12) , 973-6, (1992)

Sennosides A and C directly injected into the caecum of mice showed equal purgative activity. Intracaecal administration reduced time to onset of diarrhoea induced by sennoside C from about 3 h after ...