orellanine

Names

[ Name ]:
orellanine

[Synonym ]:
3,3',4,4'-tetrahydroxy-2,2'-bipyridine-1,1'-dioxide
Orellanin
2,2'-bipyridine-3,3',4,4'-tetrol-1,1'-dioxide
Orellanine
3,3',4,4'-Tetrahydroxy-2,2'-bipyridine-N,N'-dioxide

Biological Activity

[Description]:

Orellanine is a fungal nephrotoxin. Orellanine is also a competitive inhibitor of alkaline phosphatase. Orellanine induces cell death in proximal tubular cells and in ccRCC cells. Orellanine can be used for research of clear cell renal cell carcinoma (ccRCC)[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[References]

[1]. Lyons MJ, et al. Orellanine: From Fungal Origin to a Potential Future Cancer Treatment. J Nat Prod. 2023 Jun 23;86(6):1620-1631.

[2]. Buvall L, et al. Orellanine specifically targets renal clear cell carcinoma. Oncotarget. 2017 Jul 25;8(53):91085-91098.

Chemical & Physical Properties

[ Density]:
1.777 g/cm3

[ Boiling Point ]:
834.615ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₈N₂O₆

[ Molecular Weight ]:
252.18

[ Flash Point ]:
458.558ºC

[ Exact Mass ]:
252.03800

[ PSA ]:
124.92000

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%