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Amidefrine

Names

[ CAS No. ]:
37571-84-9

[ Name ]:
Amidefrine

[Synonym ]:
Amidephrine

Biological Activity

[Description]:

Amidephrine is a selective agonist of alpha 1-adrenoceptor. Amidephrine inhibits inhibits monopulse field contraction of the vas deferens epithelium and prostate gland[1].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

α1-adrenergic receptor


[In Vitro]

Amidephrine (10-100 nM) 在年轻成年大鼠和老年大鼠输精管的上皮和前列腺中，剂量依赖性地抑制单脉冲场收缩，EC50 分别为 6.79-6.48 μM 和 6.17-6.18 μM[1]。

[References]

[1]. Docherty JR, et al. An examination of age-related changes in pre- and postsynaptic alpha-adrenoceptors in the rat isolated vas deferens. Eur J Pharmacol. 1983 Nov 25;95(3-4):171-6.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H16N2O3S

[ Molecular Weight ]:
244.31100

[ Exact Mass ]:
244.08800

[ PSA ]:
86.81000

[ LogP ]:
1.85560

Related Compounds