Dichlormid

Names

[ Name ]:
Dichlormid

[Synonym ]:
ACETAMIDE, 2,2-DICHLORO-N,N-DI-2-PROPENYL-
Acetamide, N,N-diallyl-2,2-dichloro-
2,2-dichloro-N,N-di-2-propen-1-ylacetamide
N,N-Diallyldichloroacetamide
MFCD00072464
N,N-diallyl-dichloroacetamide
N,N-Diallyldichloroacetamide,Dichloromid
Dichloromid
dichlorimid
Acetamide,2,2-dichloro-N,N-di-2-propenyl
Dichlormid
GYGVN2U1&2U1
2,2-dichloro-N,N-bis(prop-2-enyl)acetamide
Acetamide,N,N-diallyl-2,2-dichloro
2,2-Dichloro-N,N-di(2-propèn-1-yl)acétamide
Acetamide, 2,2-dichloro-N,N-di-2-propen-1-yl-
Compound R-25788
2,2-dichloro-N,N-di(prop-2-en-1-yl)acetamide
2,2-Dichloro-N,N-di-2-propenylacetamide
N,N-Diallyl-2,2-dichloroacetamide
N,N-Diallyl-2,3-dichloroacetamide
EINECS 253-658-8
2,2-Dichloro-N,N-diprop-2-en-1-ylacetamide
Stauffer R-25788

Biological Activity

[Description]:

Dichlormid is a herbicide safener. Dichlormid up-regulates expression of ZmGST27 and ZmMRP1 and increases ZmGT1[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. D P Dixon, et al. Purification, Regulation and Cloning of a Glutathione Transferase (GST) From Maize Resembling the Auxin-Inducible type-III GSTs. Plant Mol Biol. 1998 Jan;36(1):75-87.

[2]. Sen Pang, et al. Co-induction of a glutathione-S-transferase, a Glutathione Transporter and an ABC Transporter in Maize by Xenobiotics. PLoS One. 2012;7(7):e40712.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
253.8±40.0 °C at 760 mmHg

[ Melting Point ]:
5.0-6.5°C

[ Molecular Formula ]:
C₈H₁₁Cl₂NO

[ Molecular Weight ]:
208.085

[ Flash Point ]:
107.3±27.3 °C

[ Exact Mass ]:
207.021774

[ PSA ]:
20.31000

[ LogP ]:
1.98

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.495

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB6080000

CHEMICAL NAME :: Acetamide, N,N-diallyl-2,2-dichloro-

CAS REGISTRY NUMBER :: 37764-25-3

BEILSTEIN REFERENCE NO. :: 1768843

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C8-H11-Cl2-N-O

MOLECULAR WEIGHT :: 208.10

WISWESSER LINE NOTATION :: GYGVN2U1&2U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 3,109,1976/1977

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5500 mg/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,251,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,251,1991

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H332

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;N: Dangerous for the environment;

[ Risk Phrases ]:
R43;R50/53

[ Safety Phrases ]:
S45

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
AB6080000

Precursor & DownStream

Precursor

DownStream

Articles

Fatty acid elongation is important in the activity of thiocarbamate herbicides and in safening by dichlormid.

J. Exp. Bot. 54(385) , 1289-94, (2003)

The thiocarbamates, such as pebulate (S-propyl butyl (ethyl) thiocarbamate) are a well-established class of herbicides. They inhibit fatty acid elongation, which is necessary for the biosynthesis of c...

The inhibition of fatty acid elongation by pebulate can be effectively counteracted by the safener dichlormid.

Biochem. Soc. Trans. 28(6) , 650-1, (2000)

The thiocarbamate herbicide pebulate inhibits fatty acid elongation, which is necessary for surface lipid biosynthesis. As both barley and wild oats are susceptible to pebulate, the safener dichlormid...

Induction of glutathione S-transferases in Arabidopsis by herbicide safeners.

Plant Physiol. 130(3) , 1497-505, (2002)

Herbicide safeners increase herbicide tolerance in cereals but not in dicotyledenous crops. The reason(s) for this difference in safening is unknown. However, safener-induced protection in cereals is ...