6-Hydroxykynurenic acid

Names

[ Name ]:
6-Hydroxykynurenic acid

[Synonym ]:
6-Hydroxykynurenic acid
4,6-dihydroxy-2-carboxyquinoline
6-Hydroxykynureninsaeure
4,6-dihydroxy-quinoline-2-carboxylic acid
Quinaldic acid,4,6-dihydroxy
6-Hydroxykynurensaeure
6-Hydroxykynurenate
4,6-Dihydroxyquinaldic acid
4,6-Dihydroxy-chinolin-2-carbonsaeure

Biological Activity

[Description]:

6-Hydroxykynurenic acid (6-HKA) is a derivative of kynurenic acid (KYNA) and can be isolated from Ginkgo leaves. 6-Hydroxykynurenic acid is a low-affinity NMDAR antagonist (IC50: 59 μM)[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

IC50: 59 μM (NMDAR)[1]

[References]

[1]. Weber M, et al. 6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones. J Neurochem. 2001 May;77(4):1108-15.

Chemical & Physical Properties

[ Density]:
1.569g/cm3

[ Boiling Point ]:
455.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₇NO₄

[ Molecular Weight ]:
205.16700

[ Flash Point ]:
229.4ºC

[ Exact Mass ]:
205.03800

[ PSA ]:
90.39000

[ LogP ]:
0.93190

[ Index of Refraction ]:
1.681

Safety Information

[ HS Code ]:
2933499090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%