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AK-IN-1

Names

[ CAS No. ]:
378775-98-5

[ Name ]:
AK-IN-1

[Synonym ]:
2-{[5,6-Bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}ethanol
2-[5,6-Bis-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin-4-ylamino]-ethanol
Ethanol, 2-[[5,6-bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino]-

Biological Activity

[Description]:

AK-IN-1 (compound 4072-2732) is an adenosine kinase (AK) inhibitor that is competitive for adenosine (Ado) but not for ATP. AK-IN-1 inhibits 86%, 87% and 89% of AK activity at concentrations of 2, 4 and 10 µM, respectively. AK-IN-1 has good potential for research in many disease areas, including ischaemia, inflammation and seizures[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Adenosine Kinase
Research Areas >> Cardiovascular Disease
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Adenosine Kinase

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
593.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H21N3O4

[ Molecular Weight ]:
391.42

[ Flash Point ]:
312.4±30.1 °C

[ Exact Mass ]:
391.153198

[ LogP ]:
3.05

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.648

Related Compounds