RBC6

Names

[ Name ]:
RBC6

[Synonym ]:
6-Amino-4-(3,5-dichloro-2-hydroxyphenyl)-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-4-(3,5-dichloro-2-hydroxyphenyl)-2,4-dihydro-3-propyl-

Biological Activity

[Description]:

RBC6 is an inhibitor of GTPases RalA. RBC6 inhibits binding of Ral to its effector RALBP1. RBC6 also inhibits Ral-mediated cell spreading of murine embryonic fibroblasts, as well as anchorage-independent growth of human cancer celllines[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Yan C, et al. Discovery and characterization of small molecules that target the GTPase Ral. Nature. 2014 Nov 20;515(7527):443-7.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
544.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₄Cl₂N₄O₂

[ Molecular Weight ]:
365.214

[ Flash Point ]:
283.3±30.1 °C

[ Exact Mass ]:
364.049377

[ LogP ]:
3.75

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.691