VU0420373

Names

[ Name ]:
VU0420373

Biological Activity

[Description]:

VU0420373 is a potent heme sensor system (HssRS) activator with an EC50 of 10.7 μM and a pEC50 of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus[1].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Metabolic Disease

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

EC50: 10.7 μM (HssRS)[1] pEC50: 4.97 (HssRS)[1]

[In Vitro]

VU0420373 (compound 2e) has an IC50 of >60 μM for Newman aerobic and Newman anaerobic, respectively[1]. VU0420373 (40 μM; 2, 4, 6, 8 hours) is able to preadapt S. aureus to a toxic concentration of heme (20 μM)[1].

[References]

[1]. Brendan F Dutter, et al. Decoupling Activation of Heme Biosynthesis From Anaerobic Toxicity in a Molecule Active in Staphylococcus Aureus. ACS Chem Biol. 2016 May 20;11(5):1354-61.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₁FN₂O

[ Molecular Weight ]:
254.25900

[ Exact Mass ]:
254.08600

[ PSA ]:
48.91000

[ LogP ]:
3.58840

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport