Eucannabinolide

Names

[ Name ]:
Eucannabinolide

[Synonym ]:
germacranolide eucannabinolide
Hiyodorilactone A
Eucannabinolide
Eucannabinolid
Schkuhrin I
(E)-4-Hydroxy-2-hydroxymethyl-2-butenoic acid (3aR,4R,6E,9S,10Z,11aR)-9-acetoxy-2,3,3a,4,5,8,9,11a-octahydro-6,10-dimethyl-3-methylene-2-oxocyclodeca[b]furan-4-yl ester
Hyodorilactone A

Biological Activity

[Description]:

Eucannabinolide is a STAT3 inhibitor. Eucannabinolide suppresses STAT3 activation at tyrosine 705, inhibiteds its translocation to nucleus, and decreases its DNA binding capacity. Eucannabinolide can be used for triple negative breast cancer (TNBC) diseases research[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> STAT

[References]

[1]. Zhu Z, et al. Eucannabinolide, a novel sesquiterpene lactone, suppresses the growth, metastasis and BCSCS-like traits of TNBC via inactivation of STAT3. Neoplasia. 2021 Jan;23(1):36-48.

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Boiling Point ]:
618.9ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₈O₈

[ Molecular Weight ]:
420.45

[ Flash Point ]:
211.5ºC

[ Exact Mass ]:
420.17800

[ PSA ]:
119.36000

[ LogP ]:
1.52510

[ Index of Refraction ]:
1.555

Safety Information

[ Hazard Codes ]:
Xi

Eucannabinolide

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds