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Adaptaquin

Names

[ CAS No. ]:
385786-48-1

[ Name ]:
Adaptaquin

[Synonym ]:
MFCD02655485
8-Quinolinol, 7-[(4-chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-
7-{(4-Chlorophenyl)[(3-hydroxypyridin-2-yl)amino]methyl}quinolin-8-ol
7-{(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl}-8-quinolinol

Biological Activity

[Description]:

Adaptaquin is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PHD2), with an IC50 of 2 μM. Adaptaquin can inhibit lipid peroxidation and maintain mitochondrial function[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Research Areas >> Metabolic Disease

[Target]

IC50: 2 μM (HIF-PHD2)[1]


[References]

[1]. Smirnova NA, et, al. Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation. Chem Biol. 2010 Apr 23;17(4):380-91.

[2]. Neitemeier S, et, al. Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis. 2016 May 5;7(5):e2214.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
650.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H16ClN3O2

[ Molecular Weight ]:
377.824

[ Flash Point ]:
347.4±31.5 °C

[ Exact Mass ]:
377.093109

[ LogP ]:
4.63

[ Appearance of Characters ]:
Tan solid

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.753

[ Storage condition ]:
Store at -20℃

[ Water Solubility ]:
Soluble to 100 mM in DMSO

Related Compounds