methyl 3-oxo-3-(6-(trifluoromethyl)pyridin-3-yl)propanoate

Names

[ Name ]:
methyl 3-oxo-3-(6-(trifluoromethyl)pyridin-3-yl)propanoate

[Synonym ]:
MFCD01862654

Biological Activity

[Description]:

11β-HSD1-IN-8 (compound c6a) is a 11β‑HSD1 inhibitor with an IC50 value of 2.3 μM for human 11β‑HSD1. 11β-HSD1-IN-8 can be used for the research of diabetes and cognitive decline[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

[Target]

IC50: 2.3 μM (human 11β‑HSD)[1]

[In Vitro]

11β-HSD1-IN-8 (0-50 μM) inhibits human and rat 11β‑HSD1 with IC50 values of 2.3 μM and ＞50 μM, respectively[1].

Chemical & Physical Properties

[ Density]:
1.341g/cm3

[ Boiling Point ]:
295.5ºC at 760 mmHg

[ Melting Point ]:
60-62ºC

[ Molecular Formula ]:
C₁₀H₈F₃NO₃

[ Molecular Weight ]:
247.17100

[ Flash Point ]:
132.5ºC

[ Exact Mass ]:
247.04600

[ PSA ]:
56.26000

[ LogP ]:
1.84620

[ Index of Refraction ]:
1.459

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933399090

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%