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3-epi-betulinic acid

Names

[ CAS No. ]:
38736-77-5

[ Name ]:
3-epi-betulinic acid

[Synonym ]:
(3β,17α)-3-Hydroxylup-20(29)-en-28-oic acid
Betulininsaeure
Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3β,17α)-
(3α)-3-Hydroxylup-20(29)-en-28-oic acid
Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3α)-
betulic acid
Betulin-saeure
3-epi-betulinic acid

Biological Activity

[Description]:

Epibetulinic acid, isolated from the root bark of Maytenus cuzcoina and the leaves of Maytenus chiapensis, exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC50s of 0.7 and 0.6 μM, respectively. Anti-inflammatory activity[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Research Areas >> Inflammation/Immunology

[Target]

PGE2:0.6 μM (IC50)

NO:0.7 μM (IC50)


[References]

[1]. Reyes CP, et al. Activity of lupane triterpenoids from Maytenus species as inhibitors of nitric oxide and prostaglandin E2. Bioorg Med Chem. 2006 Mar 1;14(5):1573-9.

Chemical & Physical Properties

[ Density]:
1.1±0.0 g/cm3

[ Boiling Point ]:
550.0±0.0 °C at 760 mmHg

[ Melting Point ]:
277℃

[ Molecular Formula ]:
C30H48O3

[ Molecular Weight ]:
456.700

[ Flash Point ]:
300.5±0.0 °C

[ Exact Mass ]:
456.360352

[ PSA ]:
57.53000

[ LogP ]:
8.94

[ Vapour Pressure ]:
0.0±0.0 mmHg at 25°C

[ Index of Refraction ]:
1.533

[ Storage condition ]:
2-8C

Precursor & DownStream

Precursor

DownStream

Related Compounds