Z-Guggulsterone
Names
[ CAS No. ]:
39025-23-5
[ Name ]:
Z-Guggulsterone
[Synonym ]:
Guggulsterone
(17E)-Pregna-4,17-diene-3,16-dione
(17Z)-Pregna-4,17(20)-diene-3,16-dione 4,17(20)-trans-Pregnadiene-3,16-dione
UNII:9B259YE66O
Pregna-4,17(20)-diene-3,16-dione, (17E)-
(17E)-Pregna-4,17(20)-diene-3,16-dione
Z-Guggulsterone,(Z)-Pregna-4,17(20)-diene-3,16-dione
E-guggulsterone
Pregna-4,17-diene-3,16-dione, (17E)-
trans-Guggulsterone
GUGGULSTERONE, (E)-
Biological Activity
[Description]:
[Related Catalog]:
[Target]
VEGF-R2
Akt
[In Vitro]
[In Vivo]
[References]
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
463.3±45.0 °C at 760 mmHg
[ Melting Point ]:
188-190°
[ Molecular Formula ]:
C21H28O2
[ Molecular Weight ]:
312.446
[ Flash Point ]:
172.3±25.7 °C
[ Exact Mass ]:
312.208923
[ PSA ]:
34.14000
[ LogP ]:
3.65
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.557
[ Storage condition ]:
2-8°C
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R37
[ Safety Phrases ]:
S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
Precursor & DownStream
Precursor
DownStream
Articles
Nat. Chem. Biol. 3(5) , 268-273, (2007)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.Nat. Chem. Biol. 5 , 765-71, (2009)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...
Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone.Biochim. Biophys. Acta 1844(9) , 1684-93, (2014)
Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative...